研究実績

2023

• p53 Preservers Centrosome Integrity in Cep169-depleted Cells through the Mitotic Surveillance Pathway

Anju Haeno, Kanako Terada, Midori Ishige, Sohya Yamakawa, Takuya Ootsuka, Taiki Arai, Mone Yamasaki, Soichiro Kumamoto, Reiko Ohki, Yasuhiko Terada

10th International MDM2 Workshop (2023.10.18) 【ポスター発表】

第46回分子生物学会 (2023.12.6) 【ポスター発表・口頭発表】

2022

• Disassembly of Polycomb Complex during mitosis regulates Accurate Chromosome Distribution through CDK-mediated phosphorylation of PHC2

　 第45回分子生物学会 (2022.12.1) 【ポスター・口頭発表】

2021

• Centromeric SET oncogene product, a PP2A inhibitor, induces a chromosomal instability by activating Aurora B kinase

　 第80回日本癌学会学術総会 (2021.09.30) 【学会発表】

2020

• SET/TAF1 forms a distance-dependent feedback loop with Aurora B and Bub1 as a tension sensor at centromeres.

Asai Y, Matsumura R, Hasumi Y, Susumu H, Nagata K, Watanabe Y, Terada Y. (2020) Sci. Rep.10;15653

2019

• Aurora-B kinase activity is regulated by SET/TAF1 on Sgo2 at the inner centromere.

Asai Y, Fukuchi K, Tanno Y, Koitabashi-Kiyozuka S, Kiyozuka T, Noda Y, Matsumura R, Koizumi T, Watanabe A, Nagata K, Watanabe Y and Terada Y*. (2019) J Cell Biol. 7;218(10):3223-3236

2018

• Identification of the Cep169-interacting proteins and the in vivo modification sites of Cep169 via proteomic analysis.

Shintomi M, Shiratori M, Negishi L, Terada Y. (2018) Biochem Biophys Res Commun. 15;495(3):2275-2281

2015

• Phosphorylation of Cep169 by Cdk1 promotes its dissociation from centrosomes in mitosis.

Mori Y, Inoue Y, Taniyama Y, Tanaka S, Terada Y. (2015) Biochem Biophys Res Commun. 25;468(4):642-646

• Microtubule-bundling activity of the centrosomal protein, Cep169, and its binding to microtubules.

Mori Y, Taniyama Y, Tanaka S, Fukuchi H, Terada Y,  (2015) Biochem Biophys Res Commun. 27;467(4):754-759

• Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein, Binds to CDK5RAP2 and Regulates Microtubule Stability.

Mori Y, Inoue Y, Tanaka S, Doda S, Yamanaka S, Fukuchi H, Terada Y.  (2015) PLos One. 20;10(10):e0140968.

2012

• Mechanical impulses can control metaphase progression in a mammalian cell.

Itabashi T, Terada Y, Kuwana K, Kan T, Shimoyama I, Ishiwata S. (2012) Proc Natl Acad Sci USA. 109(19):7320–7325

• Asymmetric and highly stereoselective synthesis of the def-ring moiety of (-)-FR182877 and its derivative inducing mitotic arrest.

Kobayakawa Y, Mori Y, Okajima H, Terada Y, Nakada M. (2012) Organic Letters, 14(8):2086-2089

2006

• HIV-1 Vpr induces G2 checkpoint activation by interacting with the splicing factor SAP145.

Terada Y*. Yasuda Y. (2006) Mol Cell Biol. 26:8149-8158

• Aurora-B/AIM-1 regulates the dynamic behavior of HP1 alpha at the G2-M transition.

Terada Y*. (2006) Mol Biol Cell. 17(7):3232-3241

2004

• The MAP kinase pathway is required for entry into mitosis and cell survival.

Liu X, Yan S, Zhou T, Terada Y, Erikson RL. (2004) Oncogene, 23(3):763-776

• Cdc42 and mDia3 regulate microtubule attachment to kinetochores.

Yasuda S, Oceguera-Yanez F, Kato T, Okamoto M, Yonemura S, Terada Y, Ishizaki, Narumiya S. (2004) Nature, 428(6984):767-771

2003

• Interaction of Aurora-A and centrosomin at the microtubule-nucleating site in Drosophila and mammalian cells.

Terada Y*, Uetake Y, Kuriyama R. (2003) J Cell Biol. 162(5):757-763

• Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process.

Goto H, Yasui Y, Kawajiri A, Nigg EA, Terada Y, Tatsuka M, Nagata KI, Inagaki M. (2003) J Biol Chem. 278(10):8526-8530

• Localization, dynamics, and function of survivin revealed by expression of functional survivinDsRed fusion proteins in the living cell.

Temme A, Rieger M, Reber F, Lindemann D, Weigle B, Diestelkoetter-Bachert P, Ehninger G, Tatsuka M, Terada Y, Rieber EP. (2003)  Mol Biol Cell. 14(1):78-92

• Phosphorylation of threonine-210 and the role of serine-137 in the regulation of mammalian polo-like kinase.

Jang YJ, Ma S, Terada Y, Erikson RL. (2002) J. Biol Chem. 277(46):44115-44120

2001

• Role of chromosomal passenger complex in chromosome segregation and cytokinesis. Cell Struct Funct.

Terada Y. (2001) Cell Struct Funct. 26(6):653-657

• Downregulation of an AIM-1 kinase couples with megakaryocytic polyploidization of human hematopoietic cells.

Kawasaki A, Matsumura I, Miyagawa Ji, Ezoe S, Tanaka H, Machii T, Terada Y, Tatsuka M, Machii T, Miyazaki H, Furukawa Y, Kanakura Y. (2001) J Cell Biol. 152(2):275-287

• AIM-1 regulates onset of cytokinesis by targeting INCENP to midzone and midbody.

Terada Y, Katayama H, Tatsuka M, Kuriyama R. (2001) Mol. Biol. Cell Supple. 11, 1777

1998

• Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase, AIM-1, in human cancer cells.
Tatsuka M, Katayama H, Ota T, Tanaka T, Odashima S, Suzuki F, Terada Y. (1998) Cancer Res. 58(21):4811-4816

• AIM-1: a mammalian midbody-associated protein required for cytokinesis.
Terada Y*, Tatsuka M, Suzuki F, Yasuda Y, Fujita S, Otsu M. (1998) EMBO J. 17(3):667-676

1995

• Requirement for tyrosine phosphorylation of Cdk4 in G1 arrest induced by ultraviolet irradiation.
Terada Y, Tatsuka M, Jinno S, Okayama H. (1995) Nature. 379(6538):358-362

• Ultraviolet light-induced G1 arrest is linked to CDK4 phosphorylation.
Terada Y. (1995) Molecular Biology of Cancer, Implication for Prevention and Therapy, A-50

和文総説

• 寺田泰比古：Aurora-B による染色体分配と細胞質分裂のコーディネーション (2004) 実験医学12月号　22(18):2626-2632
• 寺田泰比古：核分裂から細胞質分裂へ (2002) 生体の科学, 53(3):209-214
• 寺田泰比古：Ｍ期ヒストンH3キナーゼだったAIM-1 (M期制御と癌研究の新たな展開) (2001) 遺伝子医学,  5:682-685
• 寺田泰比古：G2/M期チェックポイント異常と染色体不安定性, (1998) 実験医学, 16:1631-1637
• 寺田泰比古：チェックポイントとp53 (1995) Surgery Frontier, 2(4):13-17
• 寺田泰比古：細胞周期研究法 (1995) 実験医学別冊
• 寺田泰比古：G1チェックポイント機構 (1995) Biomedical Perspectives, 4(3):311-317