2012年度
論文
Sepe, V.; Ummarino, R.; D'Auria, M. V.; Taglialatela-Scafati, O.; D'Amore, C.; Renga, B.; Nakao, Y.; Fusetani, N.; Fiorucci, S.; Zampella, A.; Marino, S.; Chini, M.; Bifulco, G. Preliminary Structure-Activity Relationship on Theonellasterol, a New Chemotype of FXR Antagonist, from the Marine Sponge Theonella swinhoei Mar. Drugs, 10, 2448-2466, (2012).
Ishigami, S.-T.; Goto, Y.; Inoue, N.; Kawazu, S.-I.; Matsumoto, Y.; Imahara, Y.; Tarumi, M.; Nakai, H.; Fusetani, N.; Nakao, Y. Cristaxenicin A, an antiprotozoal xenicane diterpenoid from the deep sea gorgonian Acanthoprimnoa cristata J. Org. Chem., 77, 10962-10966, (2012).
Umehara, M.; Negishi, T.; Tashiro, T.; Nakao, Y.; Kimura, J. Structure-related cytotoxic activity of derivatives from kulokekahilide-2, a cyclodepsipeptide in Hawaiian marine mollusk Bioorg. Med. Chem. Lett. 22, 7422-7425, (2012).
Takada, Y.; Umehara, M.; Katsumata, R.; Nakao, Y.; Kimura, J. The total synthesis and structure-activity relationships of a highly cytotoxic depsipeptide kulokekahilide-2 and its analogs Tetrahedron, 68, 659-669, (2012).
著書・総説
Nakao, Y.; Fusetani, N. Enzyme Inhibitors from Maine Invertebrates, In Marine Natural Products Handbook, Springer, Vol. 2, pp. 1145-1229, (2012).
海外招待講演
Nakao ,Y. “Anti-parasitic agents from marine organisms” Asian Natural Products and Chemical Biology 中国杭州 2012 年 11 月．
新聞報道
日経産業新聞（2012.01.25）
2011年度
論文
Murayama, S.; Imae, Y.; Takada, K.; Kikuchi, J.; Nakao, Y.; van Soest, R. W. M.; Okada, S.; Matsunaga, S. Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata Bioorg. Med. Chem. 19, 6594-6598, (2011).
Shengule, S.R.; Loa-Kum-Cheung, W. L.; Parish, C. R.; Blairvacq, M.; Meijer, L.; Nakao, Y.; Karuso, P. A One-pot Synthesis and Biological Activity of Ageladine A and Analogues J. Med. Chem. 54, 2492-2503, (2011).
Takaku, M.; Kanuma, T.; Ishida, T.; Ishigami, S.; Suzuki, H.; Tashiro, S.; van Soest, R. W. M.; Nakao, Y.; Kurumizaka, H. Halenaquinone, a Chemical Compound That Specifically Inhibits the Secondary DNA Binding of RAD51 Genes to Cells. 16, 427-436, (2011).
著書・総説
酵素阻害剤『マリンバイオテクノロジーの新展開』、児玉公一郎・中尾洋一、 伏谷伸宏監修、シーエムシー出版、pp.74-92、東京、(2011).
「海洋天然有機化合物が拓くケミカルバイオロジー」、児玉公一郎・中尾洋 一、日経BPムック、早稲田大学産学連携レビュー ’11、pp.18-20、東京、(2011).
新聞報道
日本経済新聞全国版（2011.03.01）
2010年度
著書・総説
Nakao, Y.; Fusetani, N. Marine Invertebrates: Sponges. In Comprehensive Natural Products ; Chemistry II Chemistry and Biology; Mander, L.; Lui, H.-W., Eds. Elsevier: Oxford, , Vol. 2, pp. 327-362, (2010).
2009年度
原著論文
Ueoka, R.; Nakao, Y.; Kawatsu, S.; Yaegashi, J.; Matsumoto, Y.; Matsunaga, S.; Furihata, K.; van Soest, R. W. M.; Fusetani, N. Gracilioethers A-C, Anti-malarial Metabolites from the Marine Sponge Agelas gracilis J. Org. Chem. 74, 4204-4207, (2009).
Umehara, M.; Takada, Y.; Nakao, Y.; Kimura, J. Intramolecular Ester Exchange of Potent Cytotoxic Kulokekahilide-2 Tetrahedron Lett. 50, 840-843, (2009).
Yamashita, T.; Nakao, Y.; Matsunaga, S.; Oikawa, T.; Imahara, Y.; Fusetani, N. A New Antiangiogenic C24 Oxylipin from the Soft Coral Sinularia numerosa Bioorg. Med. Chem. 17, 2181-2184, (2009).
2008年度
原著論文
Araki, T.; Matsunaga, S.; Nakao, Y; Furihata, K; West, L; Faulkner, D. J.; Fusetani, N. Koshikamide B, a cytotoxic peptide lactone from a marine sponge Theonella sp. J. Org. Chem. 73, 7889-7894, (2008).
Murayama, S.; Nakao, Y.; Matsunaga, S. Asteropterin, an Inhibitor of Cathepsin B, from the Marine Sponge Asteropus simplex Tetrahedron Lett. 49, 4186-4188, (2008).
Ueoka, R.; Nakao, Y.; Fujii, S.; van Soest, R. W. M.; Matsunaga, S. Aplysinoplides A-C, Cytotoxic Manoalide Derivatives from the Marine Sponge Aplysinopsis digitata J. Nat. Prod. 71, 1089-1091, (2008).
Nakao,Y.; Narazaki, G.; Hoshino, T.; Maeda,S.; Yoshida, M.; Maejima, H.; Yamashita, J. K. Evaluation of Antiangiogenic Activity of Azumamides by the in vitro Vascular Organization Model Using Mouse Induced Pluripotent Stem (iPS) Cells Bioorg. Med. Chem. Lett. 18, 2982-2984, (2008).
Nakao, Y.; Kawatsu, S.; Okamoto, C.; Okamoto, M.; Matsumoto, M.; Matsunaga, S.; van Soest,R. W. M.; Fusetani, N. Ciliatamides A-C, Bioactive Lipopeptides from the Deep-sea Sponge Aaptos ciliata J. Nat. Prod. 71, 469-472, (2008).
Takada, Y.; Umehara, M.; Nakao, Y.; Kimura, J. Revised absolute stereochemistry of natural kulokekahilide-2, Tetrahedron Lett. 49, 1163-1165, (2008).
国際シンポジウム
Nakao, Y. “Search for Chemical-“Epi”genetic Probes from Marine Invertebrates” Waseda-NUS Joint Symposium, Chemical Epigenomics -The fusion of Epigenetics, Stem Cell Biology and Chemical Biology.（主催）
Nakao, Y. “Marine Natural Products as Tool for Chemical Biology” The Second Waseda-NTU Symposium in Chemistry 2009.
2007年度
原著論文
Okamoto, C.; Nakao, Y.; Fujita, T.; Iwashita, T.; van Soest, R. W. M.; Fusetani, N.; Matsunaga, S. Cytotoxic C47-Polyacetylene Carboxylic Acids from a Marine Sponge Pertrosia sp., J. Nat. Prod. 70, 1816-1819, (2007).
Umeda, Y.; Furihata, K.; Sakuda, S.; Nagasawa, H.; Ishigami, K.; Watanabe, H.; Izumikawa, M.; Takagi, M.; Doi, D.; Nakao, Y.; Shin-ya, K. Absolute Structure of Prunustatin A, a Novel GRP78 Molecular Chaperone Down-Regulator, Org. Lett. 9, 4239-4242, (2007).
Takada, Y.; Mori, E.; Umehara, M.; Nakao, Y.; Kimura, J. Reinvestigation of the stereochemistry of kulokekahilide-2, Tetrahedron Lett. 48, 7653-7656, (2007).
Meketa, M. L.; Weinreb, S. M.; Nakao, Y.; Fusetani, N. Application of a 6π-1-Azatriene Electrocyclization Strategy to Total Synthesis of the Marine Sponge Metabolite Ageladine A and Biological Evaluation of Synthetic Analogues, J. Org. Chem. 72, 4892-4899, (2007).
Kobayashi, H.; Miyata, Y.; Okada, K.; Fujita, T.; Iwashita, T.; Nakao, Y.; Fusetani, N.; Matsunaga, S. The Structures of Three New Shishididemniols from a Tunicate of the Family Didemnidae, Tetrahedron 63, 6748-6754, (2007).
Wen, S.; Carey, K. L.; Nakao, Y.; Fusetani, N.; Packham, G.; Ganesan A. Total Synthesis of Azumamide A and Azumamide E, Evaluation as Histone Deacetylase Inhibitors, and Design of a More Potent Analogue, Org Lett. 9, 1105-1108, (2007).
Kobayashi, H.; Kitamura, K.; Nagai, K.; Nakao, Y.; Fusetani, N.; van Soest, R. W. M.; Matsunaga, S. Carteramine A, an inhibitor of neutrophil chemotaxis, from the marine sponge Stylissa carteri, Tetrahedron Lett. 48, 2127–2129, (2007).
Kobayashi, H.; Ohashi, J.; Fujita, T.; Iwashita, T.; Nakao, Y.; Matsunaga, S.; Fusetani, N. Complete Structure Elucidation of Shishididemniols, Complex Lipids with Tyramine-Derived Tether and Two Serinol Units, from a Marine Tunicate of the Family Didemnidae, J. Org. Chem. 72, 1218-1225, (2007).
総説
Nakao, Y.; Fusetani, N. Enzyme Inhibitors from Maine Invertebrtes, J. Nat. Prod. 70, 689-710, (2007).
国際学会招待講演
Nakao, Y. “Bioactive small molecules from marine organisms” Symposium A: Aquatic Ecosystems, 4th Asia-Pacific Conference on Chemical Ecology.