Personal Profile

教授小出隆規
Takaki KOIDE, Ph.D.
Professor

京都大学薬学部製薬化学科卒業
京都大学大学院薬学研究科博士課程修了
博士（薬学）

和歌山県生まれ　大学院修了後、製薬メーカー、Joslin Diabetes Center、京都大学再生医科学研究所、徳島大学工学部、新潟薬科大学をへて2007年より現職

Publications (1999- )

市瀬慎一郎、小出隆規
コラーゲン様ペプチド超分子
コラーゲンの製造と応用展開Ⅱ 105-112 (2013)

C. M. Yamazaki, I. Nakase, H. Endo, S. Kishimoto, Y. Mashiyama, R. Masuda, S. Futaki, T. Koide*
Collagen-like Cell-penetrating Peptides
Angew. Chem. Int. Ed. Engl. 52, 5497-5500 (2013)

H. Yasui, C. M. Yamazaki, H. Nose, C. Awada, T. Takao, T. Koide*
Potential of Collagen-like Triple Helical Peptides as Drug Carriers: Their In vivo Distribution, Metabolism and Excretion Profiles in Rodents.
Biopolymers (Peptide Science) 100, 705-713 (2013)

小出隆規*
コラーゲン３重らせんを模倣するペプチドの創薬およびバイオマテリアルへの応用
薬学雑誌 133(3), 387-392 (2013)

M. Yagi-Utsumi, S. Yoshikawa, Y. Yamaguchi, Y. Nishi, E. Kurimoto, Y. Ishida, T. Homma, J. Hoseki, Y. Nishikawa, T. Koide, K. Nagata, K. Kato*
NMR and mutational identification of the collagen-binding site of chaperone Hsp47
PLoS One 7(9), e45930 (2012)

S. T. L. Philominathan*, T. Koide, O. Matsushita, J. Sakon
Bacterial collagen-binding domain targets under-twisted regions of collagen
Protein Sci. 21, 1554-1565 (2012)

小出隆規*
コラーゲン三重らせんペプチドのデザイン、合成と応用
遺伝子医学MOOK 21, 217-222 (2012)

S. Matsui, C. M. Yamazaki, T. Koide*
Surface-modifiable free-floating films formed by multiway connection of collagen-like triple-helical peptides
Macromol. Rapid Commun. 33, 911-915 (2012)

A. Sekiya, S. Oishi, N. Fujii, T. Koide
High-throughput turbidimetric screening for heparin-neutralizing agents and low-molecular-weight heparin mimetics
Chem. Pharm. Bull. 60(3), 371-376 (2012)

A. Sekiya, H. Okano-Kosugi, C.M. Yamazaki, T. Koide
Identification of angiogenic regulatory domains of fibril-forming collagens using collagen-like triple helical peptides
Peptide Science 2011, 29-32 (2012)

関谷敦志、小出隆規
コラーゲン結合性多機能SERPIN、色素上皮由来因子（PEDF）の構造－機能相関
酵素工学ニュース 66, 20-24 (2011)

A. Sekiya, H. Okano-Kosugi, C.M. Yamazaki, T. Koide*
Pigment epithelium-derived factor (PEDF) shares binding sites in collagen with heparin/heparan sulfate proteoglycans
J. Biol. Chem. 286, 26364-26374 (2011)

小出隆規*
コラーゲン様三重らせんペプチドを利用した生化学研究（総説）
生化学 82, 474-483 (2010)

Y. Nishikawa, Y. Takahara, S. Asada, A. Shigenaga, A. Otaka, K. Kitagawa, T. Koide*
A structure-activity relationship study elucidating the mechanism of sequence-specific collagen recognition by the chaperone HSP47.
Bioorg. Med. Chem. 18, 3767-3775 (2010)

C. M. Yamazaki, Y. Kadoya, K. Hozumi, H. Okano-Kosugi, S. Asada, K. Kitagawa, M. Nomizu, T. Koide*
A collagen-mimetic triple helical supramolecule that evokes integrin-dependent cell responses.
Biomaterials 31, 1925-1934 (2010)

H. Okano-Kosugi, O. Matsushita, S. Asada, A. B. Herr, K. Kitagawa, T. Koide*
Development of a high-throughput screening system for the compounds that inhibit collagen-protein interactions.
Anal. Biochem. 394, 125-131 (2009)

C. M. Yamazaki, S. Asada, K. Kitagawa, T. Koide*
Totally synthetic collagen-like gels by intermolecular folding of designed peptides. (Proceeding for 30th European Peptide Symposium)
Peptides 2008, 458-459 (2009)

S.T.L. Philominathan*, T. Koide, K. Hamada, H. Yasui, S. Seifert, O. Matsushita, J. Sakon
Unidirectional binding of clostridial collagenase to triple helical substrates
J. Biol. Chem. 284, 10868-10876 (2009)

C. M. Yamazaki, S. Asada, K. Kitagawa, T. Koide*
Artificial Collagen Gels via Self-assembly of De Novo Designed Peptides
Biopolymers(Peptide Science) 90, 816-823 (2008)

T. Koide*
Designed triple-helical peptides as tools for collagen biochemistry and matrix engineering
Philos. Trans. Royal Soc. B. 362, 1281-1291 (2007)

T. Koide*, Y. Nishikawa, S. Asada, C. M. Yamazaki, Y. Takahara, D. L. Homma, A. Otaka, K. Ohtani, N. Wakamiya, K. Nagata, K. Kitagawa
Specific recognition of the collagen triple helix by chaperone HSP47. II. The HSP47-binding structural motif in collagens and related proteins
J. Biol. Chem. 281, 11177-11185 (2006)

T. Koide*, S. Asada, Y. Takahara, Y. Nishikawa, K. Nagata, K. Kitagawa
Specific recognition of the collagen triple helix by chaperone HSP47. Minimal structural requirement and spatial molecular orientation
J. Biol. Chem. 281, 3432-3438 (2006)

T. Koide*, D. L. Homma, S. Asada, K. Kitagawa
Self-assembly of Self-complementary Peptides to Form Collagen-like Triple-helical Supramolecules (Proceeding)
Peptide Science 2005, 97-98 (2006)

Y. Nishikawa, C. M. Yamazaki, S. Asada, D. L. Homma, A. Otaka, K. Nagata, K. Kitagawa, T. Koide*
HSP47-Binding Structural Epitopes in Triple Helical Collagen. (Proceeding)
Peptide Science 2005, 79-80 (2006)

T. Koide*
Triple helical collagen-like peptides: engineering and applications in matrix biology
Connect. Tissue Res. 46, 131-141 (2005)

J. Hosomichi, N. Yasui, T. Koide, K. Soma, I. Morita
Involvement of the collagen I-binding motif in the anti-angiogenic activity of pigment epithelium-derived factor
Biochem. Biophys. Res. Commun. 335, 756-761 (2005)

T. Koide*, K. Nagata
Collagen biosynthesis (Review)
Topics in Current Chemistry 247, 85-114 (2005)

T. Koide*, D. L. Homma, S. Asada, K. Kitagawa
Self-complementary peptides for the formation of collagen-like triple helical supramolecules
Bioorg. Med. Chem. Lett. 15, 5230-5233 (2005)

T. Koide*, Y. Nishikawa, Y. Takahara
Synthesis of heterotrimeric collagen models containing Arg residues in Y-positions and their conformational stability
Bioorg. Med. Chem. Lett. 14, 125-128 (2004)

小出隆規*
プロコラーゲンの構造形成を実現する分子シャペロンHsp47 （総説）
蛋白質　核酸　酵素　増刊号「細胞における蛋白質の一生」 49, 870-874 (2004)

N. Yasui, T. Mori, D. Morito, O. Matsushita, H. Kourai, K. Nagata, T. Koide*
Dual-site recognition of different extracellular matrix components by anti-angiogenic/neurotrophic serpin, PEDF
Biochemistry 42, 3160-3167 (2003)

N. Yasui, T. Koide*
Collagen-protein interactions mapped by phototriggered thiol introduction
J. Am. Chem. Soc. 125, 15728-15729 (2003)

T. Koide*, M. Yuguchi, M. Kawakita, H. Konno
Metal-assisted stabilization and probing of collagenous triple helices
J. Am. Chem. Soc. 124, 9388-9389 (2002)

T. Koide, Y. Takahara, S. Asada, K. Nagata
Xaa-Arg-Gly triplets in the collagen triple-helix are dominant binding sites for the molecular chaperone HSP47
J. Biol. Chem. 277, 6178-6182 (2002)

M. Matsuda, T. Koide, T. Yorihuzi, N. Hosokawa, K. Nagata
Molecular cloning of a novel ubiquitin-like protein, UBIN that binds to ER targeting signal sequences
Biochem. Biophys. Res. Commun. 280, 535-540 (2001)

O. Matsushita, T. Koide, R. Kobayashi, K. Nagata, A. Okabe
Substrate recognition of the collagen-binding domain of a Clostridium histolyticum class I collagenase
J. Biol. Chem. 276, 8761-8770 (2001)

T. Koide, Y. Takahara, S. Asada, K. Nagata, Y. Ito
Substrate Recognition of Collagen-Specific Molecular Chaperone HSP47: Contribution of Arginine Residue in the Triple Helical Substrates.(Proceeding)
Peptide Science 2000, 15912(2001)

T. Koide, A. Aso, T. Yorihuzi, K. Nagata
Conformational requirements of collagenous peptides for recognition by the chaperone protein HSP47
J. Biol. Chem. 275, 27957-27963 (2000)

T. Koide, S. Asada, K. Nagata
Interaction of Collagen-specific Molecular Chaperone HSP47 with Collagen-model Peptides.(Proceeding)
Peptide Science 1999, 17-20 (2000)

S.Asada, T. Koide and K. Nagata
Effect of HSP47 on prolyl 4-hydroxylation of collagen model peptides.
Cell Struct. Funct. 247, 187-196 (1999)

T. Koide, S. Asada, K. Nagata
Substrate Recognition of Collagen-specific Molecular Chaperone HSP47: Structural requirements and binding regulation
J. Biol. Chem. 274, 34523-34526 (1999)

今日の言葉を見る


	教授小出隆規 Takaki KOIDE, Ph.D. Professor
	京都大学薬学部製薬化学科卒業京都大学大学院薬学研究科博士課程修了博士（薬学）和歌山県生まれ　大学院修了後、製薬メーカー、Joslin Diabetes Center、京都大学再生医科学研究所、徳島大学工学部、新潟薬科大学をへて2007年より現職


Publications (1999- )
市瀬慎一郎、小出隆規コラーゲン様ペプチド超分子コラーゲンの製造と応用展開Ⅱ 105-112 (2013) C. M. Yamazaki, I. Nakase, H. Endo, S. Kishimoto, Y. Mashiyama, R. Masuda, S. Futaki, T. Koide* Collagen-like Cell-penetrating Peptides Angew. Chem. Int. Ed. Engl. 52, 5497-5500 (2013) H. Yasui, C. M. Yamazaki, H. Nose, C. Awada, T. Takao, T. Koide* Potential of Collagen-like Triple Helical Peptides as Drug Carriers: Their In vivo Distribution, Metabolism and Excretion Profiles in Rodents. Biopolymers (Peptide Science) 100, 705-713 (2013) 小出隆規* コラーゲン３重らせんを模倣するペプチドの創薬およびバイオマテリアルへの応用薬学雑誌 133(3), 387-392 (2013) M. Yagi-Utsumi, S. Yoshikawa, Y. Yamaguchi, Y. Nishi, E. Kurimoto, Y. Ishida, T. Homma, J. Hoseki, Y. Nishikawa, T. Koide, K. Nagata, K. Kato* NMR and mutational identification of the collagen-binding site of chaperone Hsp47 PLoS One 7(9), e45930 (2012) S. T. L. Philominathan, T. Koide, O. Matsushita, J. Sakon Bacterial collagen-binding domain targets under-twisted regions of collagen Protein Sci.* 21, 1554-1565 (2012) 小出隆規* コラーゲン三重らせんペプチドのデザイン、合成と応用遺伝子医学MOOK 21, 217-222 (2012) S. Matsui, C. M. Yamazaki, T. Koide* Surface-modifiable free-floating films formed by multiway connection of collagen-like triple-helical peptides Macromol. Rapid Commun. 33, 911-915 (2012) A. Sekiya, S. Oishi, N. Fujii, T. Koide High-throughput turbidimetric screening for heparin-neutralizing agents and low-molecular-weight heparin mimetics Chem. Pharm. Bull. 60(3), 371-376 (2012) A. Sekiya, H. Okano-Kosugi, C.M. Yamazaki, T. Koide Identification of angiogenic regulatory domains of fibril-forming collagens using collagen-like triple helical peptides Peptide Science 2011, 29-32 (2012) 関谷敦志、小出隆規コラーゲン結合性多機能SERPIN、色素上皮由来因子（PEDF）の構造－機能相関酵素工学ニュース 66, 20-24 (2011) A. Sekiya, H. Okano-Kosugi, C.M. Yamazaki, T. Koide* Pigment epithelium-derived factor (PEDF) shares binding sites in collagen with heparin/heparan sulfate proteoglycans J. Biol. Chem. 286, 26364-26374 (2011) 小出隆規* コラーゲン様三重らせんペプチドを利用した生化学研究（総説）生化学 82, 474-483 (2010) Y. Nishikawa, Y. Takahara, S. Asada, A. Shigenaga, A. Otaka, K. Kitagawa, T. Koide* A structure-activity relationship study elucidating the mechanism of sequence-specific collagen recognition by the chaperone HSP47. Bioorg. Med. Chem. 18, 3767-3775 (2010) C. M. Yamazaki, Y. Kadoya, K. Hozumi, H. Okano-Kosugi, S. Asada, K. Kitagawa, M. Nomizu, T. Koide* A collagen-mimetic triple helical supramolecule that evokes integrin-dependent cell responses. Biomaterials 31, 1925-1934 (2010) H. Okano-Kosugi, O. Matsushita, S. Asada, A. B. Herr, K. Kitagawa, T. Koide* Development of a high-throughput screening system for the compounds that inhibit collagen-protein interactions. Anal. Biochem. 394, 125-131 (2009) C. M. Yamazaki, S. Asada, K. Kitagawa, T. Koide* Totally synthetic collagen-like gels by intermolecular folding of designed peptides. (Proceeding for 30th European Peptide Symposium) Peptides 2008, 458-459 (2009) S.T.L. Philominathan, T. Koide, K. Hamada, H. Yasui, S. Seifert, O. Matsushita, J. Sakon Unidirectional binding of clostridial collagenase to triple helical substrates J. Biol. Chem.* 284, 10868-10876 (2009) C. M. Yamazaki, S. Asada, K. Kitagawa, T. Koide* Artificial Collagen Gels via Self-assembly of De Novo Designed Peptides Biopolymers(Peptide Science) 90, 816-823 (2008) T. Koide* Designed triple-helical peptides as tools for collagen biochemistry and matrix engineering Philos. Trans. Royal Soc. B. 362, 1281-1291 (2007) T. Koide, Y. Nishikawa, S. Asada, C. M. Yamazaki, Y. Takahara, D. L. Homma, A. Otaka, K. Ohtani, N. Wakamiya, K. Nagata, K. Kitagawa Specific recognition of the collagen triple helix by chaperone HSP47. II. The HSP47-binding structural motif in collagens and related proteins J. Biol. Chem.* 281, 11177-11185 (2006) T. Koide, S. Asada, Y. Takahara, Y. Nishikawa, K. Nagata, K. Kitagawa Specific recognition of the collagen triple helix by chaperone HSP47. Minimal structural requirement and spatial molecular orientation J. Biol. Chem.* 281, 3432-3438 (2006) T. Koide, D. L. Homma, S. Asada, K. Kitagawa Self-assembly of Self-complementary Peptides to Form Collagen-like Triple-helical Supramolecules (Proceeding) Peptide Science* 2005, 97-98 (2006) Y. Nishikawa, C. M. Yamazaki, S. Asada, D. L. Homma, A. Otaka, K. Nagata, K. Kitagawa, T. Koide* HSP47-Binding Structural Epitopes in Triple Helical Collagen. (Proceeding) Peptide Science 2005, 79-80 (2006) T. Koide* Triple helical collagen-like peptides: engineering and applications in matrix biology Connect. Tissue Res. 46, 131-141 (2005) J. Hosomichi, N. Yasui, T. Koide, K. Soma, I. Morita Involvement of the collagen I-binding motif in the anti-angiogenic activity of pigment epithelium-derived factor Biochem. Biophys. Res. Commun. 335, 756-761 (2005) T. Koide, K. Nagata Collagen biosynthesis (Review) Topics in Current Chemistry* 247, 85-114 (2005) T. Koide, D. L. Homma, S. Asada, K. Kitagawa Self-complementary peptides for the formation of collagen-like triple helical supramolecules Bioorg. Med. Chem. Lett.* 15, 5230-5233 (2005) T. Koide, Y. Nishikawa, Y. Takahara Synthesis of heterotrimeric collagen models containing Arg residues in Y-positions and their conformational stability Bioorg. Med. Chem. Lett.* 14, 125-128 (2004) 小出隆規* プロコラーゲンの構造形成を実現する分子シャペロンHsp47 （総説）蛋白質　核酸　酵素　増刊号「細胞における蛋白質の一生」 49, 870-874 (2004) N. Yasui, T. Mori, D. Morito, O. Matsushita, H. Kourai, K. Nagata, T. Koide* Dual-site recognition of different extracellular matrix components by anti-angiogenic/neurotrophic serpin, PEDF Biochemistry 42, 3160-3167 (2003) N. Yasui, T. Koide* Collagen-protein interactions mapped by phototriggered thiol introduction J. Am. Chem. Soc. 125, 15728-15729 (2003) T. Koide, M. Yuguchi, M. Kawakita, H. Konno Metal-assisted stabilization and probing of collagenous triple helices J. Am. Chem. Soc.* 124, 9388-9389 (2002) T. Koide, Y. Takahara, S. Asada, K. Nagata Xaa-Arg-Gly triplets in the collagen triple-helix are dominant binding sites for the molecular chaperone HSP47 J. Biol. Chem. 277, 6178-6182 (2002) M. Matsuda, T. Koide, T. Yorihuzi, N. Hosokawa, K. Nagata Molecular cloning of a novel ubiquitin-like protein, UBIN that binds to ER targeting signal sequences Biochem. Biophys. Res. Commun. 280, 535-540 (2001) O. Matsushita, T. Koide, R. Kobayashi, K. Nagata, A. Okabe Substrate recognition of the collagen-binding domain of a Clostridium histolyticum class I collagenase J. Biol. Chem. 276, 8761-8770 (2001) T. Koide, Y. Takahara, S. Asada, K. Nagata, Y. Ito Substrate Recognition of Collagen-Specific Molecular Chaperone HSP47: Contribution of Arginine Residue in the Triple Helical Substrates.(Proceeding) Peptide Science 2000, 15912(2001) T. Koide, A. Aso, T. Yorihuzi, K. Nagata Conformational requirements of collagenous peptides for recognition by the chaperone protein HSP47 J. Biol. Chem. 275, 27957-27963 (2000) T. Koide, S. Asada, K. Nagata Interaction of Collagen-specific Molecular Chaperone HSP47 with Collagen-model Peptides.(Proceeding) Peptide Science 1999, 17-20 (2000) S.Asada, T. Koide and K. Nagata Effect of HSP47 on prolyl 4-hydroxylation of collagen model peptides. Cell Struct. Funct. 247, 187-196 (1999) T. Koide, S. Asada, K. Nagata Substrate Recognition of Collagen-specific Molecular Chaperone HSP47: Structural requirements and binding regulation J. Biol. Chem. 274, 34523-34526 (1999)
今日の言葉を見る